Bioadhersive drug delivery systems have high gastric duration due to adherence with mucous membrane of biosubstrate therefore it''s used as controlled unleash and targeted drug delivery system. Bioadhesion is that the method by that a natural or an artificial polymer will adhere to a biological substrate and provides the action for extended length of time. Bioadhersive controlled-release devices will improve the effectiveness of a drug by maintaining the drug concentration between the effective and poisonous levels, inhibiting the dilution of the drug within the body fluids, and permitting targeting and localization of a drug at a specific site. In recent years several such bioadhersive drug delivery systems are developed for oral, buccal, nasal, rectal and vaginal routes for each general and native effects. This paper shows special attention on gi dose forms along with ideas, mechanism of mucoadhesion, factors affecting mucoadhesion, various polymers used, evaluation methods, recent advances and future aspects.
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